Buffer solutions are used in the pharmaceutical industry to maintain the pH value of drug compounds, ensuring their stability, solubility and biological activity while improving the purity of certain components. Pfanstiehl’s range of buffer components includes TRIS Base, TRIS HCl, Sodium Succinate Hexahydrate and Succinic Acid.
TRIS Base USP EP BP ChP cGMP Injectable Excipient-Grade
Tris Base is used widely in biologics production and a number of biochemical and molecular biology applications. As a zwitterionic amine, its structure includes both acidic and basic functional groups, allowing it to function as an effective buffer over a wide pH range.
Benefits of Pfanstiehl’s high-purity, low-endotoxin Tris Base include pH stability, biocompatibility, water solubility, low UV absorbance, buffering capacity, non-toxicity, and versatility of uses.
https://pfanstiehl.com/en/high-purity-ingredients/tris-base
TRIS HCl cGMP Injectable Excipient-Grade
The chemical compound TRIS HCl is used widely in the pharmaceutical industry, playing a vital role in maintaining a stable pH environment. Its pH-regulating properties, biocompatibility, versatility, stability, and minimal interference with biochemical processes make it a valuable buffering component for pharmaceutical applications.
TRIS HCl takes the form of a white crystalline powder that is highly soluble in water, allowing it to be incorporated easily into various pharmaceutical formulations.
https://pfanstiehl.com/en/high-purity-ingredients/tris-hcl/
Sodium Succinate (Hexahydrate) NF JPE cGMP Injectable Excipient-Grade
Pfanstiehl provides a hexahydrate form of sodium succinate, the sodium salt of succinic acid, which is suitable for various pharmaceutical manufacturing applications. These include use as a buffering agent or stabiliser, for improving the solubility of certain drugs, integration into drug delivery systems, for preventing oxidative degradation in pharmaceutical formulations, and in affecting their metabolism and cellular processes.
https://pfanstiehl.com/en/high-purity-ingredients/sodium-succinate-hexahydrate/
Succinic Acid USP/NF EP BP JP ChP cGMP Injectable Excipient-Grade
Succinic acid is a dicarboxylic acid that naturally occurs in various plants and animals. It is a key intermediate in the citric acid cycle (Krebs cycle), a metabolic pathway that generates energy in cells.
The role of succinic acid in biologic formulations is to maintain the biologic product’s stability, efficacy and safety throughout its shelf life and while being administered. The practical applications for which it is suitable include injectable biologics, vaccines, lyophilised products, and topical and oral biologics.
https://pfanstiehl.com/en/high-purity-ingredients/succinic-acid/