Using the STYL’One Nano Compaction Simulator to Characterise Round and Oblong Itraconazole Amorphous Solid Dispersions Tablets

By MEDELPHARM

Itraconazole (ITZ) is an antifungal drug commercially available as an oral solution or more commonly as 100mg capsules. It has been reported that the bioavailability of the oral solution is only 55%.

One of the strategies to improve its solubility, and therefore its bioavailability, is to produce amorphous solid dispersions (ASDs) using the hot melt extrusion (HME) process.

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