Drug Manufacturers, Technology, Therapy Area

Terminology in Pharmacy – Thermal Analysis Provides the Overall Picture

By NETZSCH Group

Standard ASTM E2550 describes the thermal stability of a material as the “temperature at which the material starts to decompose or react and the extent of mass change using thermogravimetry”. It adds that “the absence of reaction or decomposition is used as an indication of the thermal stability”.

By means of thermal analysis, particularly DSC and TGA, the different properties of API and excipients can be investigated. This, in turn, allows for the determination of the thermal stability, compatibility and polymorphism and pseudo-polymorphism of pharmaceuticals.

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