The Critical Role of Predictive Bioreactor Characterisation in Pharmaceutical Process-Based Upscaling

By ZETA

In bioreactors, microorganisms or cell cultures produce complex therapeutic proteins and other biopharmaceuticals.

The industrial production of those active pharmaceutical ingredients usually involves a seed train: the cells are run through many cultivation systems, which become larger with each passage (Upstream Process). An adequate number of cells for the inoculation of large-scale production bioreactors of 10,000l or more is generated.

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