Addressing the Gassing Rate in Bioreactor Upscaling – Is VVM a Reliable Parameter?

By ZETA

Common approaches for the scale-up of bioreactors use the gas flow coefficient (vvm) as a criterion for volumetric flow rates. Besides being the most common decisive parameter when it comes to the scaling of the gassing rate, a defined vvm is frequently used in the context of process validation, and therefore considered essential for qualification.

ZETA called the reliability of this parameter into question and evaluated the scaling competence of vvm in a study performed in the context of commissioning an upstream production plant. Based on the results of the study, ZETA strongly recommends not relying solely on this parameter, as it would certainly produce erroneous results in scaling.

To read more, please download this free white paper.

Enter your details below to view the free white paper

By downloading this whitepaper, you acknowledge that GlobalData may share your information with our white paper partners/sponsors who may contact you directly with information on their products and services.

Visit our Privacy Policy for more information about our services, how GlobalData may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.