Modifying MDI Canister Surfaces to Improve Drug Stability and Delivery

Hydrofluoroalkane (HFA) based propellants are widely used in modern metered-dose inhalers (MDI) due to their lack of hazardous and environmentally damaging effects. However, a HFA's active pharmaceutical ingredient (API) can interact with the canister substrate and cause deposition of the drug to the canister walls. The substrate could also interact with the solution, causing degradation and increased impurity levels. Over the past few years, a number of surface coatings have been developed that can be applied to MDI canisters and valve components to protect the contents from deposition and degradation. More recently, plasma processes have been developed to modify and improve the surface energy performance of an MDI canister. To find out more, including the range of available coatings, coating techniques, plast processing techniques, and optimisation of plasma products, download this free whitepaper.