Nose to Brain (N2B) Drug Delivery ‒ Benefits and Challenges

By Upperton Pharma Solutions

The brain/CNS is an important, yet difficult to access target for drugs used to treat a wide range of conditions from mental illness and pain management (such as migraine) through to neurodegenerative brain diseases such Alzheimer’s, ALS and Parkinson’s disease and various types of brain cancers such as neuroblastoma.

Currently, most brain/CNS therapies are administered orally and enter the brain via the systemic circulation However, in recent years, there have been a growing number of drug products approved that look to target the brain following intranasal delivery.

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