Lexitropsin Building Blocks
By Alberta Research ChemicalsThe naturally occurring oligopeptide antibiotics Netropsin and Distamycin not only represent important paradigms of sequence-selective DNA minor groove binders but also provide important direction to discover anti-cancer agents with high specificity.
Conjugation to these polyamide structures, commonly called 'Lexitropsins', has increased the specificity of other minor groove binding agents several fold.
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