Effects of Ionisable and Non-Ionisable Excipients on Lyophilised RNA Formulations Using FTIR-ATR Technology

By PerkinElmer

The Covid-19 pandemic brought mRNA messenger ribonucleic acid vaccines into international prominence. mRNA is highly unstable and storage and/or transportation of these vaccines at -80°C has been required to avoid degradation.

There are ongoing attempts to improve the storage stability of mRNA vaccines by converting them to solid forms using various drying methods. Lyophilisation is one such method and has the potential to stabilise mRNA, but there are few reports that describe the interactions of lyophilised mRNA with excipients (eg. sugars, salts and lipids) in the solid state.

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