Effects of Ionisable and Non-Ionisable Excipients on Lyophilised RNA Formulations Using FTIR-ATR Technology

By PerkinElmer

The Covid-19 pandemic brought mRNA messenger ribonucleic acid vaccines into international prominence. mRNA is highly unstable and storage and/or transportation of these vaccines at -80°C has been required to avoid degradation.

There are ongoing attempts to improve the storage stability of mRNA vaccines by converting them to solid forms using various drying methods. Lyophilisation is one such method and has the potential to stabilise mRNA, but there are few reports that describe the interactions of lyophilised mRNA with excipients (eg. sugars, salts and lipids) in the solid state.

To read more, please download this free white paper.

Enter your details below to view the free white paper

By downloading this whitepaper, you acknowledge that GlobalData may share your information with our white paper partners/sponsors who may contact you directly with information on their products and services.

Visit our Privacy Policy for more information about our services, how GlobalData may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Sections

Sections

Sections

Sections

Sections