D2F™ Pre-fillable Glass Syringes
As a leading manufacturer of high-quality pre-fillable glass syringes for the pharmaceutical industry, NIPRO offers packaging solutions precisely engineered in different quality levels (ENABLE, ENHANCE, ENGAGE) to meet the stringent demands of both standard and complex drug formulations.
Excellent compatibility between drug and container
Tungsten residues and silicone oil can interact with sensitive drug products like monoclonal antibodies and enzymes, potentially affecting their stability. To mitigate this, our D2F™ syringes are available in tungsten-free (luer) or low-tungsten (staked-needle) formats, with minimal or no silicone oil, and controlled within narrow tolerances.
We ensure 100% in-line monitoring of silicone quantity and distribution and apply advanced washing and strict inspections to reduce particulate contamination. Each batch undergoes precise particle measurement using light obscuration to meet the highest quality standards.
Designed for integration into Auto-injection Devices (AID) and for compatibility with Needle Free Connectors (NFC)
The growing use of combination products (staked needle syringe + AID) is driven by their ability to enhance convenience and adherence, support the delivery of large-volume or high-viscosity drugs, and ultimately improve patient outcomes. In parallel, needle-free connectors (NFCs) are widely adopted in healthcare settings to prevent sharps injuries and enable safer, easier intravenous administration.
D2F™ syringes are engineered for seamless integration into AIDs and compatibility with NFCs, offering high mechanical durability and precise dimensions within tight tolerances achieved through advanced forming and annealing processes. Every critical specification is inspected 100% in-line, while x-ray inspection provides an enhanced control of container closure integrity for safer, more reliable use.
Additionally, multiple parameters are controlled to guarantee a consistently smooth needle performance and needle shield removal force, optimising AID functionality and user experience. For NFCs featuring an internal blunt cannula, NIPRO offers specific luer lock syringe variants with a widened syringe tip channel, enabling safer and more secure connections.
Optimised processability for minimal rejection
We manufacture our syringes to support a seamless integration into the sophisticated workflow of our pharmaceutical customers. High-dimensional and cosmetic quality, strong mechanical durability, and reliability in processing D2F™ nest and tub formats contribute to an efficient fill-finish process and stable storage.
Standard range
- Staked needle | Luer lock | Luer slip | Nasal Spray tip
- 0,5ml | 1 std. | 1 long | 1,25ml | 1,5ml | 2,25ml | 3ml
- Bulk | D2F™ sterile packaging
- Caps | Closures | Plunger rods& stoppers | Safety system
- Silicone oil free | Backed on silicone | LInC closure with RFID | Syringe with enlarged channel
