Boehringer Ingelheim and MacroGenics have entered into a partnership to develop and commercialise antibody-based therapeutics covering multiple therapeutic areas such as immunology, respiratory, oncology and infectious diseases.
MacroGenics’ Dual-Affinity Re-Targeting (DART) platform will be used for the development of drug candidates, which will be directed against up to ten combinations of molecular targets.
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The DART platform allows for the generation of highly stable antibody-based therapeutic molecules capable of targeting two antigens simultaneously.
The two companies will share responsibility for discovery and certain pre-clinical activities, and Boehringer Ingelheim will be responsible for all subsequent clinical, regulatory, commercial and manufacturing activities for any DART-based product resulting from the collaboration.
During the first three years of collaboration, MacroGenics may receive payments totalling up to $60m, which includes an upfront cash payment, annual maintenance fees, R&D funding and near-term research-based milestones.
Boehringer expects to make a future equity investment in MacroGenics.
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By GlobalDataDepending upon the development, regulatory and commercial milestones, MacroGenics may receive up to $210m for each of the ten DART programmes.
MacroGenics may also receive tiered royalties on net product sales, and can choose to co-promote certain DART products in the US.
