IMM-1-104 is a small molecule commercialized by Immuneering, with a leading Phase II program in Pancreatic Cancer. According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of IMM-1-104’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for IMM-1-104 is expected to reach an annual total of $55 mn by 2037 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
IMM-1-104 Overview
IMM-1-104 is under development for the treatment of solid tumor, pancreatic ductal adenocarcinoma, non-small cell lung cancer, lung adenocarcinoma, cholangiocarcinoma, metastatic colorectal cancer and NRAS mutant metastatic melanoma. It is administered through oral route. The drug candidate acts by targeting mitogen activated protein kinase (MEK) and kinase suppressor of RAS (KSR). It is developed based on Immuneering artificial intelligence (AI) enabled disease cancelling technology (DCT).
Immuneering Overview
Immuneering is a biopharmaceutical company that discovers and develops oncologic and neurologic drugs. The company’s pipeline products include IMM-1-104 and IMM-6-415. Its IMM-1-104 is a dual inhibitor of mitogen-activated protein kinase (MEK) to restrain the pathway that reduces the growth of tumors. Immuneering’s IMM-6-415 candidate treats solid tumors. The company provides drug discovery services by leveraging artificial intelligence. It offers bioinformatics and computational biology services to pharmaceutical and biotechnology companies. The company operates in Massachusetts, New York and California. Immuneering is headquartered in Boston, Massachusetts, the US.
The operating loss of the company was US$58.4 million in FY2023, compared to an operating loss of US$51.7 million in FY2022. The net loss of the company was US$53.5 million in FY2023, compared to a net loss of US$50.5 million in FY2022.
For a complete picture of IMM-1-104’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
