CMN-005 is under clinical development by CoImmune and currently in Phase II for Splenic Marginal Zone B-Cell Lymphoma. According to GlobalData, Phase II drugs for Splenic Marginal Zone B-Cell Lymphoma have a 68% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how CMN-005’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

CMN-005 overview

CMN-005 is under development for the treatment of relapsed and refractory B-cell acute lymphocytic leukemia, chronic lymphocytic leukemia (CLL) and b-cell non-Hodgkin lymphoma, follicular lymphoma, marginal zone lymphoma nodal; extra-nodal; or splenic, diffuse large B-cell lymphoma, primary mediastinal large B-cell lymphoma, mantle cell lymphoma, post bone marrow transplantation. It constitutes of Chimeric Antigen Receptor (CAR) modified Cytokine Induced Killer (C.I.K.) cells. It acts by targeting the cancer cells which express CD19 antigen. The cell therapy is developed based on C.I.K. CAR technology that utilizes SB100X transposase, a component of the non-viral, Sleeping Beauty transposon-based gene transfer system. It is administered through intravenous route.

CoImmune overview

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CoImmune is a biopharmaceutical company that carries out the development and manufacture of immunotherapies to treat cancer, inflammatory and autoimmune diseases. Its clinical products pipeline includes CARCIK-CD19 (CMN-005), CAR-CIK (CMN-006), CAR-CIK solid tumors, and CMN-001. The comnpany’s products are used in the treatment of acute lymphoblastic leukemia, non-hodgkin’s lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, and metastatic renal cell carcinoma, among others. It also carries out the research and development activities through its cell therapy technology platforms which include allogeneic cytokine-induced killer (CIK) and autologous RNA-loaded dendritic cells. CoImmune is headquartered in Durham, North Carolina, the US.

For a complete picture of CMN-005’s drug-specific PTSR and LoA scores, buy the report here.