Daily Newsletter

14 November 2023

Daily Newsletter

14 November 2023

VectorY secures $138m to develop neurodegenerative disease therapies

The company will utilise the funding to support the clinical development of VTx-002 for ALS treatment.

Vishnu Priyan November 14 2023

VectorY Therapeutics has secured €129m ($138m) in a Series A funding round to progress the development of its vectorised antibody programmes in neurodegenerative diseases. 

EQT Life Sciences and Forbion Growth Opportunities Fund jointly led the financing round.

Participants comprised new and current investors, including the MRL Ventures Fund, Insight Partners, the ALS Investment Fund and Forbion Ventures.

VectorY plans to utilise the funding to support the clinical development of its lead programme, VTx-002.

VTx-002 is a vectorised antibody programme that acts on TDP-43. It will be progressed to treat amyotrophic lateral sclerosis (ALS) alongside the preclinical development of programmes targeting proteinopathies linked to neurodegenerative ailments.

Forbion general partner Wouter Joustra, EQT Life Sciences director Arno de Wilde and MRL Ventures Fund partner Karin Kleinhans will join VectorY’s board of directors.

VectorY CEO Sander van Deventer stated: “The Series A financing, supported by such a strong syndicate of European and US investors, is an endorsement of our pioneering approach, world-class team and commitment to bring much-needed therapies to patients with neurodegenerative diseases. 

“The investment will enable us to advance our lead programme VTx-002, a potentially disease-modifying therapy for ALS, into clinical development.”

Disease-modifying therapies (DMTs) entering the PD market pose significant opportunities and risks

As PD therapy currently centers on symptomatic treatment, the need for DMTs is one of the greatest unmet needs. Several companies within the late-stage PD pipeline are developing drugs that target PD via novel MOAs. Targeting α-synuclein and other neurotoxic proteins is a key strategy in the late-stage pipeline for DMTs. However, the lack of validated predictive biomarkers of PD progression have made the development of DMTs and neuroprotective agents challenging.

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