Daily Newsletter

06 October 2023

Daily Newsletter

06 October 2023

Twist Bioscience and Bayer partner for antibody discovery

Twist will receive $188m in clinical and commercial milestone payments and royalties from the deal.

RanjithKumar Dharma October 06 2023

Genomics company Twist Bioscience has entered an antibody discovery, option and licence agreement with German drug manufacturer Bayer.

Twist Bioscience’s division Twist Biopharma Solutions will use its Library of Libraries to carry out antibody discovery campaigns against targets provided by Bayer.

Twist will receive payments linked to research initiation and is also eligible to receive fees linked to milestones in research and in the exercise of licensing options.

Success-based clinical and commercial milestone payments will also be provided for antibody leads discovered under the partnership that enter clinical development. Royalties will be offered on product sales.

Twist will be eligible for $188m in clinical and commercial milestone payments and royalties, while Bayer will have exclusive rights to license the antibodies for commercialisation in territories worldwide.

Twist Bioscience CEO and co-founder Emily Leproust stated: “Our ongoing partnership with Bayer leverages the full suite of our Twist Biopharma Solutions offering of antibody discovery services to identify the best antibodies for Bayer’s specific targets.

“By combining the scientific and technical strengths of each organisation, and importantly the level of mutual trust built over several years working together, we look forward to identifying and developing new therapies in multiple disease areas to positively impact patients who need it the most.”

This is the third collaboration between the two companies. In April 2023, Twist Bioscience collaborated to help Astellas Pharma discover antibodies for immunotherapies.

Significant unmet need in the Diabetic Nephropathy (DN) market for products that can treat DN effectively without side effects

With only a few approved drugs currently available to treat DN by means other than regulation of blood pressure, innovator products that can treat by targeting other factors such as treatment of dyslipidemia, hypertension, or angiotensin inhibition, among others, is a key area of R&D in the DN space and is likely to pave the way for novel therapies in the near future. However, the treatment landscape is expected to remain unchanged due to limited availability of products in the late-stage pipeline currently.

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