Daily Newsletter

05 October 2023

Daily Newsletter

05 October 2023

Novartis split complete as Sandoz begins trading on Swiss Exchange

Novartis will now focus on innovative drugs, whilst Sandoz strengthens its biosimilar business.

Robert Barrie October 04 2023

Sandoz has completed its separation from Novartis and commenced trading under the symbol “SDZ” on the SIX Swiss Exchange.

Sandoz opened at a stock price of 24 Swiss francs on Wednesday morning. Reuters reported the company was valued at a lower-than-expected $11.2 bn (10.3bn Swiss francs).

In September, Novartis announced detailed plans on how it plans to spin-off its Sandoz subsidiary, stating its aim was to focus on being a purely innovative medicines company.

Sandoz has recorded underwhelming financials in the past years, although the subsidiary did generate record sales of $2.4bn in biosimilars in Q2 2023. Announcing the commencment of trading, Novartis said that Sandoz “is well placed for continued profitable growth as a standalone global leader and European champion in generic and biosimilar medicines.”

Sandoz states that cumulative worldwide savings due to biosimilars is estimated to reach $215bn between 2021 and 2026. An estimated 80% of medicines used worldwide by volume are generics and biosimilars.

The spin-off was conducted via distribution of a dividend-in-kind – stakeholders in the pharma giant received one Sandoz share for every five owned. The shares are being traded on Swiss Performance Index (SPI) and the Swiss Leader Index (SLI), amongst other Swiss indices. Sandoz ADRs (American Depositary Receipts) – a form of equity security for American investors – also started trading on the US OTCQX exchange as part of the split.

Sandoz has said it will now focus on filing regulatory approval for its highly anticipated Eylea (aflibercept) biosimilar.

In September the company won European approval for its Tysabri biosimilar Tyruko (natalizumab), adding to a US Food and Drug Administration (FDA) approval for its Humira biosimilar Hyrimoz (adalimumab-adaz).

Speaking in a December 2022 briefing report, GlobalData Analyst Sonnika Lamont said: “GlobalData forecasts that the expansion of biosimilars outside of oncology indications will continue to drive growth in the biopharmaceutical industry due to an increased need for outsourced manufacturing. According to McKinsey’s Biosimilar market model, this growth is set to reach $60bn by the end of the decade.”

Significant unmet need in the Diabetic Nephropathy (DN) market for products that can treat DN effectively without side effects

With only a few approved drugs currently available to treat DN by means other than regulation of blood pressure, innovator products that can treat by targeting other factors such as treatment of dyslipidemia, hypertension, or angiotensin inhibition, among others, is a key area of R&D in the DN space and is likely to pave the way for novel therapies in the near future. However, the treatment landscape is expected to remain unchanged due to limited availability of products in the late-stage pipeline currently.

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