Daily Newsletter

10 October 2023

Daily Newsletter

10 October 2023

Gates Foundation announces $40m for mRNA vaccine platform

IPD and Biovac will each receive a $5m grant to acquire the technology to develop locally relevant vaccines.

RanjithKumar Dharma October 10 2023

The Bill & Melinda Gates Foundation is providing $40m in funding to advance the accessibility of Quantoom Biosciences' affordable mRNA vaccine research and manufacturing platform.

The platform was developed with an early-research Grand Challenges grant awarded to its parent company, Univercells.

The new investments will advance access to mRNA research and vaccine manufacturing technology that will support the capacity of low and middle-income countries (LMICs) to develop vaccines at scale.

Senegal’s Institut Pasteur de Dakar and South Africa’s Biovac, both experienced in vaccine manufacturing, will each receive a $5m grant to acquire the technology to develop locally relevant vaccines.

Quantoom Biosciences will receive $20m to further advance the technology and reduce commercialisation costs.

The foundation will grant a further $10m to other LMIC vaccine manufacturers.

The new funding builds on its earlier $55m investment in mRNA manufacturing technology.

Biovac CEO Morena Makhoana stated: “This collaboration will help close critical gaps in access to promising mRNA vaccines against diseases that disproportionately affect the world’s poorest.

“It will also assist us in our mission to establish end-to-end vaccine manufacturing capability at scale in Africa for global supply.”

Leveraging Univercells’ original vaccine manufacturing technology, IPD intends to begin manufacturing essential measles and rubella vaccines.

IPD CEO Dr Amadou Sall stated: “Expanding our capacity to discover and manufacture affordable mRNA vaccines in Africa is an important and necessary step towards vaccine self-reliance in the region.”

Significant opportunities and risks for disease-modifying therapies (DMTs) entering the PD market

As PD therapy currently centers on symptomatic treatment, the need for DMTs is one of the greatest unmet needs. Several companies within the late-stage PD pipeline are developing drugs that target PD via novel MOAs. KOLs remain hopeful that these companies will uncover a class of drugs that works effectively to slow or modify the disease course. Targeting α-synuclein and other neurotoxic proteins is a key strategy in the late-stage pipeline for DMTs.

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