Daily Newsletter

15 September 2023

Daily Newsletter

15 September 2023

Cure Genetics and Frametact seek gene cures for neurological ailments

Frametact will make upfront and milestone payments totalling $60m to Cure Genetics.

Vishnu Priyan September 15 2023

China-based clinical-stage company Cure Genetics has entered a partnership and licensing deal with biotech company Frametact to develop gene therapy for familial neurological ailments.

Cure Genetics’ VELP platform will be used to develop new adeno-associated virus (AAV) vectors.

Frametact will make upfront and milestone payments totalling $60m to Cure Genetics. 

Cure Genetics is eligible to receive sales-based royalty payments on net revenue.

The partnership will merge Frametact’s broad capabilities in neurological diseases with the technology of Cure Genetics in developing AAV vectors and in vivo screening. 

The parties will join forces to develop therapies for familial neurodegenerative ailments such as Parkinson's, Alzheimer's and Huntington's disease.

This partnership follows an earlier collaboration with Boehringer Ingelheim in January 2021 to develop new AAV vectors and represents another step forward for Cure Genetics with a global company.

It validates the VELP platform’s advancement worldwide and also signifies a leap forward in the internationalisation of Cure Genetics. 

The company focuses on the development of cell and gene therapies for solid tumours, as well as genetic ailments.

Significant opportunities and risks for disease-modifying therapies (DMTs) entering the PD market

As PD therapy currently centers on symptomatic treatment, the need for DMTs is one of the greatest unmet needs. Several companies within the late-stage PD pipeline are developing drugs that target PD via novel MOAs. KOLs remain hopeful that these companies will uncover a class of drugs that works effectively to slow or modify the disease course. Targeting α-synuclein and other neurotoxic proteins is a key strategy in the late-stage pipeline for DMTs.

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