Daily Newsletter

14 September 2023

Daily Newsletter

14 September 2023

AbCellera and Incyte partner for development of cancer antibodies

AbCellera will receive research payments, downstream clinical and regulatory milestone payments and royalties for net product sales from Incyte.

Vishnu Priyan September 14 2023

AbCellera and Incyte have entered a strategic partnership for the discovery and development of therapeutic antibodies in oncology.

Incyte will gain the rights to develop and commercialise the therapeutic cancer antibodies that result from the alliance.

AbCellera will receive research payments, downstream clinical and regulatory milestone payments and royalties for net product sales from Incyte.

Incyte BioTherapeutics vice-president Patrick Mayes stated: “This collaboration supports our continued commitment to developing new therapeutics that may improve and expand treatment options for patients with cancer.

“We are excited to partner with AbCellera to initiate this research and look forward to collaborating with them to identify new antibody therapeutics that may address unmet needs in oncology.”

AbCellera focuses on rapidly making available improved medicines by breaking barriers to the standard discovery process of antibody drugs.

Its engine merges specialist teams, technology, and the data science and automation required to expedite antibody-based therapies from target to clinic in a range of therapeutic fields.

AbCellera Partnering senior vice-president Murray McCutcheon stated: “We are excited to partner with Incyte, which has a track record of developing first-in-class medicines and bringing them to patients in need.

“We look forward to working as an extension of Incyte’s team to address complex antibody discovery challenges and accelerate the development of Incyte’s preclinical pipeline of oncology medicines.”

In June 2023, AbCellera entered a research collaboration with Confo Therapeutics for the discovery of specific G protein-coupled receptor ligand (GPCR)-targeting antibody candidates.

Significant opportunities and risks for disease-modifying therapies (DMTs) entering the PD market

As PD therapy currently centers on symptomatic treatment, the need for DMTs is one of the greatest unmet needs. Several companies within the late-stage PD pipeline are developing drugs that target PD via novel MOAs. KOLs remain hopeful that these companies will uncover a class of drugs that works effectively to slow or modify the disease course. Targeting α-synuclein and other neurotoxic proteins is a key strategy in the late-stage pipeline for DMTs.

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