In the humanised ACE2 mouse model, ARDS-003 monotherapy showed to lower morbidity and mortality signs, including respiratory distress after Covid-19. Credit: NIAID / Flickr (Creative Commons).

Tetra Bio-Pharma and Cellvera have entered an agreement to jointly develop ARDS-003 as an oral combination therapeutic candidate with 400mg Qifenda (Favipiravir) for Covid-19. 

A first-in-human drug product, ARDS-003 contains the active pharmaceutical agent, Onternabez.

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Onternabez is a selective full agonist of the type 2 cannabinoid receptor (CB2R). 

ARDS-003, in preclinical studies, was found to lower the hyperinflammatory response and decelerate the progression of the disease.

In the humanised ACE2 mouse model, ARDS-003 monotherapy showed to lower morbidity and mortality signs, including respiratory distress after Covid-19 in a dose-dependent manner, versus placebo.

It is claimed to have outperformed an antiviral drug in lowering various proinflammatory mediators linked to hyperinflammation and dysfunction of the immune system after viral infection. 

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Qifenda is a broad-spectrum antiviral drug in the commercial stage.   

Developed by FujiFilm Toyama Chemical, Favipiravir is currently owned by Cellvera.

A selective viral RNA-dependent RNA polymerase (RdRP) inhibitor, Favipiravir has antiviral activity against single-stranded RNA viruses, such as coronaviruses. 

Based on findings from Prepaire, an artificial intelligence (AI)-based in-silico drug discovery platform, the companies estimate the Favipiravir plus ARDS-003 combination could aid in the quick clearance of virus and offer lasting benefits. 

Additionally, the cytokine lowering properties of ARDS-003 may avert some consequences of Covid-19, such as severe pulmonary inflammation.

Tetra Bio-Pharma CEO and CRO Guy Chamberland said: “This partnership with a pharmaceutical company with global reach is a sign of the potential for the ARDS-003 drug asset. 

“We look forward to working jointly with Cellvera to bring this combination drug product forward to improve treatment options for patients worldwide.”