TRV027 is an angiotensin II receptor type 1 (AT1 receptor) selective agonist and fights disruption within the renin-angiotensin-aldosterone system (RAAS) by attaching to and rebalancing AT1 receptor activation.
It also hinders the damaging pathway that causes acute lung damage and abnormal blood clotting.
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Additionally, it stimulates the cellular pathway that targets reparative activities that enhance lung function and boost anti-inflammatory effects.
Called ‘ACTIV-4d RAAS’, the multi-site, randomised, placebo-controlled trial has multiple treatment arms, each with 300 adult Covid-19 patients.
Coordinated by the Vanderbilt University Medical Center (VUMC) in the US, ACTIV-4d RAAS is a part of the National Heart, Lung and Blood Institute of the NIH’s Collaborating Network of Networks for Evaluating Covid-19 and Therapeutic Strategies programme.
The trial is assessing various therapies, including TRV027, that target the RAAS and will evaluate if its modulation could become a potential approach to prevent disease progression to critical illness, multiorgan failure or mortality in Covid-19 patients who are admitted to the hospital.
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By GlobalDataIt will analyse TRV027’s impact on recovery, use of supplemental oxygen, the requirement for mechanical ventilation and mortality.
Trevena president and CEO Carrie Bourdow said: “The NIH’s ongoing ACTIV public-private partnership has facilitated the unprecedented development of cutting-edge vaccines and therapeutics to fight the Covid-19 pandemic.
“Vanderbilt University Medical Center has emerged as a leader in Covid-19 research in the US, and I look forward to supporting their investigation of TRV027 as a potentially meaningful therapy for Covid-19 patients.”
In April last year, the NIH announced the ACTIV public-private partnership for developing a research plan to prioritise and expedite the development of potential therapies and vaccines.
