Lilly is testing various neutralising antibodies against Covid-19. Credit: nir_design from Pixabay.

Eli Lilly has formed a global antibody manufacturing partnership with Amgen to boost the supply capacity for its therapy candidates against Covid-19.

Currently, Lilly is testing various neutralising antibodies, as monotherapy or combination therapy, to prevent or treat the disease.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Under the collaboration, Lilly and Amgen can quickly scale up manufacturing, as well as boost global access, if one or more of Lilly’s antibody therapies succeed in clinical trials and obtain regulatory approval.

Eli Lilly chief scientific officer Daniel Skovronsky said: “Based on our initial clinical studies, we believe that virus neutralising antibodies, including LY-CoV-555, could play an important role in the fight against Covid-19.

“Increasing the manufacturing capacity for our neutralising antibodies through this collaboration with Amgen is a crucial next step, and together we hope to be able to produce many millions of doses even next year.”

According to proof-of-concept results from the BLAZE-1 clinical trial, LY-CoV555 decreased rate of hospitalisation in outpatients with symptomatic Covid-19.

The prespecified primary endpoint of change from baseline in viral load at day 11 reached the 2800mg dose level. Further analyses of viral data showed that LY-CoV555 improved viral clearance on day three.

Amgen research and development executive vice-president David Reese said: “We are impressed with Lilly’s data, in particular the reduction in hospitalisations, and are enthusiastic about the potential for these neutralising antibodies as a therapeutic for Covid-19.”

Amgen intends to leverage its technical expertise in antibody development, along with scale-up, as well as complex biologics manufacturing capabilities.

In July, Amgen made an additional investment of approximately $421m to the registered direct offering of ordinary shares of Chinese biotechnology firm BeiGene.

The investment will maintain Amgen’s existing pro-rata ownership of about 20.3% in BeiGene.