Research revealed that a single dose of the product can have an effect lasting approximately two weeks, with reduced KIT expression. Credit: Kmpzzz via Shutterstock.

Hoth Therapeutics has announced a master services agreement with Aronnax to advance the development of its HT-KIT cancer therapeutic.

HT-KIT is an antisense oligonucleotide that acts on the proto-oncogene cKIT.

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It has shown potential in reducing KIT expression and effectively killing human mast cells in both cancerous and noncancerous cells.

The research on HT-KIT, conducted at NC State University, US, revealed that a single dose can have an effect lasting approximately two weeks, with reduced KIT expression observed for seven days.

The therapeutic also demonstrated the capability to diminish KIT expression using GIST cells and to initiate cell death within 48 to 72 hours, as well as lower the expression in AML cells over a 72-hour period.

HT-KIT is being developed to treat mast cell-derived cancers and anaphylaxis and has received orphan drug designation from the US Food and Drug Administration (FDA).

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Aronnax will manage the third-party provider, ITR Laboratories, which will conduct intravenous injection studies with varying doses.

These studies will determine the maximum dose and range-finding elements crucial for Hoth’s proposed clinical trials.

The timeframe for the study includes a 48-hour interval between each dose group.

This strategic partnership aims to provide Hoth with key metrics essential for the formulation of its clinical trial proposals.

Hoth Therapeutics CEO Robb Knie said: “We continue to make quick progress in moving HT-KIT from the lab to patients. This further analysis will help us with that process, finalising the protocols in our upcoming IND-enabling study.

“We are pleased to further engage Aronnax and ITR Laboratories on these key studies given their reputation for IND-enabling studies.”

In March 2021, Hoth and the University of Cincinnati Research Institute in the US entered into a research agreement to conduct antimicrobial characterisation studies for antibiotic HT-006.