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Code Biotherapeutics and Takeda have entered a partnership and option agreement for designing and developing gene therapies to treat rare diseases.

The targeted 3DNA non-viral genetic medicine delivery platform of Code Bio will be used to develop these treatments.

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According to the collaboration, the companies will use the 3DNA platform to design and develop targeted gene therapy for a liver-directed rare disease programme.

In addition, Takeda and Code Bio will carry out further studies for central nervous system-directed programmes. 

Under the deal, Takeda holds the right to exercise options to obtain an exclusive licence for four programmes. 

Code Bio is entitled to receive upfront, near-term milestones and research funding payments in the range of double-digit million dollars from Takeda. 

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Takeda will make development and commercial milestone payments apart from tiered royalty payments in the future.

This takes the potential deal value of the collaboration to a total of up to $2bn on meeting milestones for all four programmes.

Initially, the companies will work together on research activities till the selection of the candidates. 

Following the subsequent option exercise, Takeda will oversee the development and marketing of the programmes.

​Takeda Pharmaceutical Rare Diseases Drug Discovery Unit head Madhu Natarajan said: “We aim to provide functional cures to patients with rare genetic and hematologic diseases through next-generation gene therapy programmes. 

“Code Bio’s 3DNA platform will allow us to build upon the foundation we have established through our internal capabilities and external partnerships and will hopefully enable us to develop re-dosable and durable gene therapies that will be superior to current approaches.”

The 3DNA platform can address crucial drawbacks of various other genetic medicine delivery methods permitting genetic therapies to reach their maximum potential. 

In October last year, Takeda and Immusoft signed a research and licensing agreement to develop cell therapies for rare neurometabolic disorders.

Cell & Gene Therapy Coverage on Pharmaceutical Technology supported by Cytiva.

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