Share
AstraZeneca will make an upfront payment of $100m to TeneoTwo on closing of the deal. Credit: Cheshire East Council / Flickr (Creative Commons).

AstraZeneca has signed an agreement for the acquisition of all outstanding equity of TeneoTwo as well as its CD19/CD3 T-cell engager, TNB-486, in a deal worth up to $1.27bn to bolster the haematological cancer pipeline.

As per the deal, AstraZeneca will make an upfront payment of $100m on the closing of the transaction.

Related Company Profiles

View all

Furthermore, equity holders of TeneoTwo are entitled to get up to $805m in research and development (R&D)-based milestone payments as well as up to $360m as commercial-related milestone payments from AstraZeneca.

A Phase I clinical-stage asset, TNB-486 is being analysed for relapsed and refractory B-cell non-Hodgkin lymphoma.

It attaches to CD19, an antigen expressed on B-cells, and CD3 receptor on T-cells to stimulate and recruit T-cells to CD19-expressing tumours, where they can induce an immune response.

Through the acquisition of TNB-486, AstraZeneca intends to expedite the development of this new therapy for B-cell hematologic malignancies, including diffuse large B-cell lymphoma and follicular lymphoma. 

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Building on Calquence’s (acalabrutinib) success, TNB-486 is expected to further expand the haematology pipeline of AstraZeneca that covers various therapeutic modalities and mechanisms for addressing a wide range of blood cancers.

AstraZeneca Haematology R&D senior vice-president Anas Younes said: “By redirecting the body’s natural immune response to target B-cell malignancies, TNB-486 alone or in combination with CD20-targeted therapy could potentially deepen clinical responses and improve patient outcomes. 

“We believe this innovative molecule, which was designed to optimise the therapeutic window of T-cell activation, will enable us to explore novel combinations that have the potential to become new standards of care in this setting.”

Subject to necessary conditions and approvals, the deal is anticipated to conclude in the third quarter of this year.

Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.

Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.