The drug was used in several preclinical and clinical trials to treat many CNS disorders, including Rett syndrome, and Fragile X syndrome. Credit: Ingridplg/ commons.wikimedia.org.

Anavex Life Sciences has secured new US intellectual property compositions patent for its ANAVEX 2-73 (blarcamesine).

The patent number 11,661,405 has been issued by the US Patent and Trademark Office (USPTO) and is expected to remain effective until October 2036.

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This expands the company’s patent coverage for certain ANAVEX 2-73 crystal forms preparation methods, compositions, and uses thereof, which are covered by the US patent number 10,413,519.

Anavex’s orally available drug candidate restores cellular homeostasis by targeting sigma-1 and M1 muscarinic receptors.

The company stated that the ANAVEX 2-73 compound in one of its crystal forms was used in several preclinical and clinical trials, for a wide range of CNS disorders, including Rett syndrome, Angelman syndrome, Parkinson’s disease, Fragile X syndrome, Alzheimer’s disease, Parkinson’s disease dementia, Infantile spasms, as well as other undisclosed rare CNS disorders.

The drug candidate has completed a Phase IIa and Phase IIb/III clinical trial for Alzheimer’s disease, a Phase II and a Phase III trial in Rett syndrome adult patients, and a Phase II proof-of-concept trial in Parkinson’s disease.

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Anavex Life Sciences president and CEO Christopher Missling said: “This new patent relating to ANAVEX 2-73 is exceptionally important for ANAVEX, because all clinical trials with ANAVEX 2-73 (blarcamesine), including Alzheimer’s disease Phase IIb/III ANAVEX 2-73-AD-004 study are using the patent protected crystal forms as the active pharmaceutical ingredient.

“We are extremely pleased with the continued development of the patent portfolio for ANAVEX 2-73 (blarcamesine) which demonstrates our continued commitment to protecting all aspects of the Anavex product portfolio.”