Zelenectide pevedotin is under clinical development by Bicycle Therapeutics and currently in Phase II for Pancreatic Cancer. According to GlobalData, Phase II drugs for Pancreatic Cancer have a 25% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Zelenectide pevedotin’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Zelenectide pevedotin overview
BT-8009 is under development for the treatment of solid tumors like metastatic urothelial (transitional cell) carcinoma, renal cancer, ureter cancer, urethral cancer, non-small cell lung cancer, esophageal cancer, bladder cancer, urothelial carcinoma, pancreatic cancer, gastric cancer, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, head and neck cancer and triple negative breast cancer. The drug candidate is a bicyclic peptide conjugate being developed based on bicyclic peptide technology. It acts by targeting nectin-4 linked to the cytotoxin monomethyl auristatin E (MMAE) by a molecular spacer and cleavable linker. It is administered through intravenous route.
Bicycle Therapeutics overview
Bicycle Therapeutics is a biotechnology company. It develops bicyclic peptides and Medicines for the treatment of cancers and other debilitating diseases. The company’s Bicycle conjugates include BT1718, BT5528, and BT8009; and Immuno-Oncology offers BT7480, BT7401, and BT7455. Bicycle Therapeutics proprietary bicyclic peptide technology enables the systematic cyclisation of peptides and helps to identify bicycles that provide antibody-like affinity and selectivity in a much smaller chemically synthesized molecule. The company operates with other biotechnology companies for the development of bicyclic peptide inhibitors for the treatment of ophthalmic diseases such as diabetic macular edema, renal elimination, versatility for multimerization and conjugation. It works in collaboration with Cancer Research UK(CRUK), and AstraZeneca Plc in the areas of oncology, respiratory, cardiovascular, and metabolic diseases, among others. Bicycle Therapeutics is headquartered in Cambridge, Cambridgeshire, the UK.
For a complete picture of Zelenectide pevedotin’s drug-specific PTSR and LoA scores, buy the report here.
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