Zanzalintinib fumarate is under clinical development by Exelixis and currently in Phase III for Hypopharyngeal Cancer. According to GlobalData, Phase III drugs for Hypopharyngeal Cancer does not have sufficient historical data to build an indication benchmark PTSR for Phase III. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Zanzalintinib fumarate LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Zanzalintinib fumarate overview
Zanzalintinib fumarate (XL-092) is under development for the treatment of solid tumors such as metastatic renal cell carcinoma, metastatic urothelial carcinoma including the renal pelvis, ureter, urinary bladder, urethra cancer, metastatic castration resistant prostate cancer, leiomyosarcoma, metastatic hepatocellular carcinoma, non-small cell lung cancer, papillary renal cell carcinoma, recurrent head and neck cancer squamous cell carcinoma, oral cavity cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, pancreatic NET, extra-pancreatic NET and human epidermal growth factor receptor 2 negative breast cancer (HER2- breast cancer). The drug candidate is administered through oral route. It acts by targeting protein tyrosine kinases which constitutes of MET, VEGFR, AXL and MER, TYRO3.
Exelixis overview
Exelixis is a biopharmaceutical company that focuses on the development and commercialization of small molecule therapies for the treatment of cancer. The company’s marketed products include, Cometriq (cabozantinib), an inhibitor of multiple receptor tyrosine kinases; Cabometyx (cabozantinib) developed for the treatment of patients with advanced renal cell carcinoma (RCC), and hepatocellular carcinoma (HCC). The company’s major pipeline product candidates include zanzalintinib, XB002 and XL102 for the treatment of advanced or metastatic solid tumors, and CBX-12 for advanced metastatic refractory solid tumors. The company has collaborative partnerships with biopharmaceutical companies to advance the development of potential therapies for cancer and other serious diseases. Exelixis is headquartered in Alameda, California, the US.
For a complete picture of Zanzalintinib fumarate’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
