WTX-330 is under clinical development by Werewolf Therapeutics and currently in Phase I for Colorectal Cancer. According to GlobalData, Phase I drugs for Colorectal Cancer have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how WTX-330’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
WTX-330 overview
WTX-330 is under development for the treatment of relapsed or refractory solid tumors, lymphoma, colon carcinoma, metastatic cutaneous melanoma, colorectal cancer, non-small cell lung cancer, cholangiocarcinoma, breast cancer, metastatic hormone refractory (castration resistant, androgen-independent) prostate cancer, non-hodgkin lymphoma and unspecified B cell lymphoma. The drug candidate is a systemically delivered, conditionally activated prodrug of interleukin-12 (IL-12) INDUKINE molecule, which acts by targeting interleukin 12 receptor (IL12R). It is being developed based on protein engineering technology (PREDATOR).
Werewolf Therapeutics overview
Werewolf Therapeutics is a biopharmaceutical company that discovers and develops treatments for cancer. The company investigating WTX-124, a conditionally activated interleukin-2 (IL-2) based drug to treat multiple tumor types and WTX-330 and WTX-613 drugs administered as monotherapies for refractory and immunologically unresponsive tumors. Werewolf Therapeutics utilizes its proprietary Predator protein engineering technology platform to identify, design, optimize and validate immuno-oncology, autoimmune and inflammatory disease product candidates. It’s protein engineering technology integrates protein design elements to improve activity, stability and tumor selectivity within a single molecule. Werewolf Therapeutics is headquartered in Cambridge, Massachusetts, the US.
For a complete picture of WTX-330’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
