WP-1066 is under clinical development by Moleculin Biotech and currently in Phase I for Pediatric Diffuse Intrinsic Pontine Glioma. According to GlobalData, Phase I drugs for Pediatric Diffuse Intrinsic Pontine Glioma does not have sufficient historical data to build an indication benchmark PTSR for Phase I. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the WP-1066 LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
WP-1066 overview
WP-1066 is under development for the treatment of metastatic melanoma, glioblastoma, head and neck tumors, bladder cancer, renal cancer, ovarian cancer, stomach cancer, pancreatic cancer, brain tumors, pediatric diffuse intrinsic pontine gliomas (DIPG), ependymoma, recurrent or refractory medulloblastoma, acute myeloid leukemia, ocular tumor and recurrent malignant glioma. It is administered through oral and intravenous route. WP-1066 is small molecule Degrasyn drug candidate inhibitor of the PD-L1 and STAT3 pathway. It selectively promotes degradation of vital proteins that are involved in tumor cell proliferation and survival. Degrasyn is an inhibitor of the Janus kinase/signal transducer and activation of transcription (JAK/STAT) pathway. It exerts anti-tumor activity in tumors by inhibiting key growth and survival signaling (JAK/STAT) pathways.
Moleculin Biotech overview
Moleculin Biotech (MBI) is a clinical-stage pharmaceutical company that primarily focuses on developing therapeutic candidates for hard-to-treat tumors and viruses. The company’s lead program, annamycin, develops for the treatment of relapsed or refractory acute myeloid leukemia (AML) and soft tissue sarcoma (STS) lung metastases. The company’s portfolio also includes WP1066, an immune and transcription modulator for targeting various cancers, and WP1122, an antimetabolite for potential treatment of viruses and certain cancer indications. MBI products are primarily aimed at patients suffering from specific types of cancer and viral diseases. The company primarily operates in the U.S. MBI is headquartered in Houston, Texas, the US.
For a complete picture of WP-1066’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
