Voxelotor is under clinical development by Pfizer and currently in Phase III for Leg Ulcers. According to GlobalData, Phase III drugs for Leg Ulcers does not have sufficient historical data to build an indication benchmark PTSR for Phase III. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Voxelotor LoA Report. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Voxelotor overview
Voxelotor (Oxbryta) is a hematologic agent. It is formulated as film coated tablets for oral route of administration. Voxelotor is indicated for the treatment of sickle cell disease (SCD) in adults and pediatric patients 12 years of age and older. Oxbryta is indicated for the treatment of hemolytic anemia due to sickle cell disease (SCD) in adults and pediatric patients 12 years of age and older, either as monotherapy or in combination with hydroxycarbamide.
Voxelotor (GBT-440) is under development for the treatment of sickle cell disease and leg ulcers in patients with sickle cell disease. The therapeutic candidate is administered through oral route. It acts by targeting hemoglobin. The drug candidate is developed based on Shape platform. The drug candidate was under development for the treatment of acute hypoxemic pulmonary fibrosis.
Pfizer overview
Pfizer discovers, develops, manufactures, and commercializes biopharmaceuticals. The company offers products to treat various conditions such as cardiovascular, metabolic and pain, women’s health, cancer, inflammation, immune disorders, and rare diseases. It also provides sterile injectable pharmaceuticals, biosimilars, active pharmaceutical ingredients (APIs) and contract manufacturing services. Pfizer sells its products through wholesalers, retailers, hospitals, individual provider offices, clinics, government agencies, and pharmacies. It has major manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US. The company provides its products in North America, South America, Asia-Pacific, Australia, Europe, Africa, and the Middle East. Pfizer is headquartered in New York, the US.
For a complete picture of Voxelotor’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
