VG-161 is under clinical development by Virogin Biotech and currently in Phase II for Metastatic Hepatocellular Carcinoma (HCC). According to GlobalData, Phase II drugs for Metastatic Hepatocellular Carcinoma (HCC) have a 21% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how VG-161’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
VG-161 overview
VG-161 is under development for the treatment of hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, pancreatic ductal adenocarcinoma, acinar cell carcinoma, adenosquamous carcinoma, metastatic hepatocellular carcinoma, intrahepatic cholangiocarcinoma, sarcoma, metastatic gastric or gastroesophageal junction adenocarcinoma, bone sarcoma, soft tissue sarcoma, Ewing sarcoma and colon cancer. The drug candidate is an oncolytic virus.It is an attenuated herpes simplex virus type 1 (HSV-1), developed based on Virogin’s Synerlytic Platform, VG161 has a deletion of the ICP34.5 gene to prevent neurovirulence. It is administered through intratumor route. It acts by targeting interleukin-12, interleukin-15, interleukin-15 receptor subunit alpha and programmed cell death 1 ligand 1 (PD-L1).
Virogin Biotech overview
Virogin Biotech is a pharmaceutical company. It develops immunotherapies and oncolytic virotherapies that improve systemic antitumor immunity using oncolytic HSV-1 platform and Prime-Boost Approach. The company’s pipeline products include VG161, VG201, VG203, VG301, VGXXX. Its pipeline candidates treat Attenuated (ICP 34.5 deletion), and tumors. The company works in collaboration with research institutes, biotechnology, and pharmaceutical companies. It operates research and development hubs in Vancouver, Canada; and Shanghai, China. Virogin Biotech is headquartered in Vancouver, British Colombia, Canada.
For a complete picture of VG-161’s drug-specific PTSR and LoA scores, buy the report here.
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