Veligrotug is under clinical development by Viridian Therapeutics and currently in Phase III for Graves’ Ophthalmopathy. According to GlobalData, Phase III drugs for Graves’ Ophthalmopathy have a 50% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Veligrotug’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Veligrotug overview
Veligrotug (AVE-1642) is under development for Grave's ophthalmopathy (thyroid eye disease). It is administered through intravenous, subcutaneous and parenteral route. It is a humanized monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R/CD221) with potential antineoplastic activity. The drug candidate is developed by using proprietary TAP technology.
It was under development for the treatment of recurrent, refractory multiple myeloma, advanced or metastatic liver carcinoma and advanced hormono dependent breast cancer.
Viridian Therapeutics overview
Viridian Therapeutics (Viridian), formerly miRagen Therapeutics, focuses on the discovery and development of medicines for serious and rare diseases. The company’s major products in development are VRDN-001 and VRDN-003, which are aimed at treating thyroid eye disease (TED), and a portfolio of neonatal Fc receptor (FcRn) inhibitors, including VRDN-006 and VRDN-008, for autoimmune diseases. The company’s lead product candidate VRDN-001 is an intravenous humanized monoclonal antibody targeting IGF-1R, and VRDN-003 for subcutaneous administration, both aimed at treating thyroid eye disease (TED). The company develops novel RNA-based therapeutics, with a core focus on therapeutic antibodies and their roles in diseases. Viridian is headquartered in Waltham, Massachusetts, the US.
For a complete picture of Veligrotug’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
