VE-303 is under clinical development by Vedanta Biosciences and currently in Phase III for Clostridioides difficile Infections (Clostridium difficile Associated Disease). According to GlobalData, Phase III drugs for Clostridioides difficile Infections (Clostridium difficile Associated Disease) have a 36% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how VE-303’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
VE-303 overview
VE-303 is under development for the treatment of hepatic encephalopathy and Clostridium difficile infections. It is administered through oral route in the form of capsule. The drug candidate consists of a defined consortium of live bacteria. It acts by modulating pathways of interaction between the human microbiome and the host immune system to treat inflammatory diseases.
It was also under development for the treatment of colitis.
Vedanta Biosciences overview
Vedanta Biosciences, a subsidiary of Puretech Health Plc, clinical-stage microbiome company that develops oral therapies based on defined bacterial consortia. The company’s pipeline products include VE303, VE202, VE800, VE707 and VE416. Its products treat clostridioides difficile (CDI) infection, inflammatory bowel disease (IBD), immuno-oncology, carbapenem-resistant Enterobacteriaceae (CRE), vancomycin-resistant Enterococci (VRE), extended-spectrum beta-lactamase producers (ESBL), and food allergy. Vedanta Bioscience’s proprietary discovery and development platform enables the identification of defined bacterial consortia with drug-like properties. Its manufacturing facility enables the production of bacterial consortia and handles multiple drug candidates for clinical studies and commercial launches. The company works in collaboration with Bristol Myers Squibb Inc, Biomedical Advanced Research and Development Agency (BARDA), JSR Corp, Leiden University Medical Center, Vall d’Hebron Institute of Oncology, NYU Langone Medical Center and others for research and development. Vedanta Biosciences is headquartered in Cambridge, Massachusetts, the US.
For a complete picture of VE-303’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
