TYRA-300 is a small molecule commercialized by Tyra Biosciences, with a leading Phase II program in Solid Tumor. According to Globaldata, it is involved in 3 clinical trials, of which 2 are ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of TYRA-300’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for TYRA-300 is expected to reach an annual total of $63 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
TYRA-300 Overview
Tyra-300 is under development for the treatment of metastatic urothelial carcinoma of the bladder and urinary tract, solid tumors, achondroplasia and hypochondroplasia. The drug candidate acts by targeting fibroblast growth factor (FGF) receptor 3. It is being developed based on SNAP platform. It is administered by oral route.
Tyra Biosciences Overview
Tyra Biosciences (Tyra) is a biotechnology company that specializes in the development of innovative molecular structures. Its products are its next-generation drug candidates, that are designed to provide deeper responses and overcome resistance to currently available treatments, particularly in the field of oncology. Tyra Biosciences’ pipeline includes several drugs targeting FGFR mutations, such as Tyra-300 and Tyra-200, that are being developed for various applications including cancer treatment and addressing skeletal dysplasias. Its products are primarily aimed at improving small molecule drug discovery and development in targeted oncology and genetically defined conditions. The company operates in the US. Tyra is headquartered in Carlsbad, California, the US.
The operating loss of the company was US$79.9 million in FY2023, compared to an operating loss of US$58.9 million in FY2022. The net loss of the company was US$69.1 million in FY2023, compared to a net loss of US$55.3 million in FY2022.
For a complete picture of TYRA-300’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
