TYRA-200 is a small molecule commercialized by Tyra Biosciences, with a leading Phase I program in Bile Duct Cancer (Cholangiocarcinoma). According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of TYRA-200’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for TYRA-200 is expected to reach an annual total of $19 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
TYRA-200 Overview
Tyra-200 is under development for the treatment of FGFR2 mutated intrahepatic cholangiocarcinoma, endometrial cancer and solid tumors. It acts by targeting fibroblast growth factor receptor 1, receptor 2, receptor3 (FGFR1/23). it is administered through oral route.
Tyra Biosciences Overview
Tyra Biosciences (Tyra) is a precision oncology company that design and develop cancer drugs. It is investigating Tyra-300, an FGFR3 (fibroblast growth factor receptor 3) inhibitor targeting bladder and solid tumors. The company evaluates FGFR2 small molecule inhibitor for the treatment of bile duct and solid tumors; FGFR3 (ACH) program against achondroplasia; an RET-specific inhibitor for lung and thyroid cancer; and FGFR4-specific inhibitor liver and solid tumors. It utilizes SNAP, a proprietary in-house discovery engine to discover and develop molecular structures for cancer. Tyra is headquartered in Carlsbad, California, the US.
The operating loss of the company was US$79.9 million in FY2023, compared to an operating loss of US$58.9 million in FY2022. The net loss of the company was US$69.1 million in FY2023, compared to a net loss of US$55.3 million in FY2022.
For a complete picture of TYRA-200’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
