TNG-908 is under clinical development by Tango Therapeutics and currently in Phase II for Pancreatic Ductal Adenocarcinoma. According to GlobalData, Phase II drugs for Pancreatic Ductal Adenocarcinoma does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the TNG-908 LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TNG-908 overview
TNG-908 is under development for the treatment of MTAP-deleted cancers like cholangiocarcinoma, mesothelioma, squamous and non squamous non-small cell lung cancer, bladder cancer, malignant peripheral nerve sheath tumor (MPNST) glioblastoma multiforme, colon cancer, pancreatic ductal adenocarcinoma and soft tissue sarcoma. It is administered through oral route. It acts by targeting the protein arginine methyltransferase 5 (PRMT5) enzyme.
Tango Therapeutics overview
Tango Therapeutics is a biotechnology company that discovers and develops novel drug targets for the treatment of cancer. The company is investigating TNG908, a synthetic lethal small molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) against methylthioadenosine phosphorylase (MTAP) deleted cancers. It also develops PRMT5 TNG462 for MTAP-deleted tumors; CoREST TNG260 for STK11-mutant cancers; USP1 TNG348 for BRCA1 and BRCA2-mutant and HRD+ cancers. It works in collaboration with Gilead Sciences to discover, develop, and commercialize cancer therapies. Tango Therapeutics is headquartered in Boston, Massachusetts, the US.
For a complete picture of TNG-908’s drug-specific PTSR and LoA scores, buy the report here.
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