TNG-462 is under clinical development by Tango Therapeutics and currently in Phase II for Pancreatic Ductal Adenocarcinoma. According to GlobalData, Phase II drugs for Pancreatic Ductal Adenocarcinoma does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the TNG-462 LoA Report. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TNG-462 overview
TNG-462 is under development for the treatment of solid tumors with MTAP (methylthioadenosine phosphorylase) deletion include non-small cell lung cancer, squamous non-small cell lung cancer, mesothelioma, soft tissue sarcomas, pancreatic ductal adenocarcinoma. The drug candidate is a next-generation protein arginine methyl transferase 5 (PRMT5) inhibitor. It is administered through oral route.
It was also under development for malignant peripheral nerve sheath tumor (MPNST) and cholangiocarcinoma.
Tango Therapeutics overview
Tango Therapeutics is a biotechnology company that discovers and develops novel drug targets for the treatment of cancer. The company is investigating TNG908, a synthetic lethal small molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) against methylthioadenosine phosphorylase (MTAP) deleted cancers. It also develops PRMT5 TNG462 for MTAP-deleted tumors; CoREST TNG260 for STK11-mutant cancers; USP1 TNG348 for BRCA1 and BRCA2-mutant and HRD+ cancers. It works in collaboration with Gilead Sciences to discover, develop, and commercialize cancer therapies. Tango Therapeutics is headquartered in Boston, Massachusetts, the US.
For a complete picture of TNG-462’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
