TmEGFR/IL13Ralpha2 01 CAR-T is under clinical development by Kite Pharma and currently in Phase I for Recurrent Glioblastoma Multiforme (GBM). According to GlobalData, Phase I drugs for Recurrent Glioblastoma Multiforme (GBM) have an 87% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how TmEGFR/IL13Ralpha2 01 CAR-T’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TmEGFR/IL13Ralpha2 01 CAR-T overview
The therapeutic candidate is under development for the treatment of recurrent glioblastoma. It comprises autologous T cells genetically engineered to express chimeric antigen receptor (CAR) targeting cells expressing IL13RA2 and epidermal growth factor receptor (EGFR). It is administered through intrathecal route.
Kite Pharma overview
Kite Pharma, a subsidiary of Gilead Sciences Inc, is a biopharmaceutical company that discovers and develops cancer immunotherapy products. Kite Pharma provides products like Chimeric Antigen Receptors(CAR), KTE-C19 DLBCL, PMBCL, TFL (ZUMA-1); Chemo Refractory Diffuse Large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma (PMBCL), transformed follicular lymphoma (TFL), KTE-C19 MCL (ZUMA-2); Relapsed/Refractory Mantle Cell Lymphoma (MCL), KTE-C19 Adult and Pediatric ALL (ZUMA-3, ZUMA-4); Acute Lymphoblastic Leukemia (ALL), Axicabtagene ciloleucel; 2L+ high-risk follicular lymphoma, Axicabtagene ciloleucel; 1L high-risk large B-cell lymphoma, Axicabtagene ciloleucel; 2L large B-cell lymphoma outpatient, Brexucabtagene autoleucel; Basket (rare B-cell malignancies). It carries out the Kite External Research Program service. It works in collaboration with various institutes and companies. The company has an operational presence in the UK, Netherlands and the US. Kite Pharma is headquartered in Santa Monica, California, the US.
For a complete picture of TmEGFR/IL13Ralpha2 01 CAR-T’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
