Tildacerfont is a small molecule commercialized by Spruce Biosciences, with a leading Phase II program in Congenital Adrenal Hyperplasia (Adrenogenital Syndrome). According to Globaldata, it is involved in 11 clinical trials, of which 6 were completed, 2 are ongoing, 2 are planned, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Tildacerfonts valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
Smarter leaders trust GlobalData
The revenue for Tildacerfont is expected to reach an annual total of $51 mn by 2035 in the US based off GlobalDatas Expiry Model. The drugs revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drugs phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Tildacerfont Overview
Tildacerfont (SPR-001) is under development for the treatment of classic congenital adrenal hyperplasia, major depressive disorder (MDD) and polycystic ovary syndrome. The drug candidate is a small molecule formulated as a capsule and tablet, administered through oral route. It acts by targeting corticotropin-releasing factor receptor-1. It was under development for the treatment of cushing's disease.
Spruce Biosciences Overview
Spruce Biosciences is a biopharmaceutical company that develops and commercializes drugs, novel therapies for the rare endocrine disorders with significant unmet medical need. It’s product pipeline include Tildacerfont, a CRF1 receptor antagonist to treat adult and pediatric classic congenital adrenal hyperplasia and polycystic ovary syndrome. Spruce Biosciences focuses on reducing the hyperresponsiveness of adrenocorticotropic hormone (ACTH), a hormone involved in the production of cortisol and improve disease control and glucocorticoid steroid burden. The company offers services such as medical services, healthcare services, clinical trials among others. Spruce Biosciences is headquartered in South San Francisco, California, the US.
The company reported revenues of (US Dollars) US$10.1 million for the fiscal year ended December 2023 (FY2023). The operating loss of the company was US$52 million in FY2023, compared to an operating loss of US$47.3 million in FY2022. The net loss of the company was US$47.9 million in FY2023, compared to a net loss of US$46.2 million in FY2022.
The company reported revenues of US$2 million for the first quarter ended March 2024, a decrease of 30.7% over the previous quarter.
For a complete picture of Tildacerfonts valuation, buy the drugs risk-adjusted NPV model (rNPV) here.
Data Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
