Spruce Biosciences has been granted a patent for a method to treat PCOS-FAH by administering a CRF1 antagonist. The treatment targets elevated adrenal androgens, addressing symptoms like hirsutism and infertility. GlobalData’s report on Spruce Biosciences gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Spruce Biosciences, Peptide pharmacophores was a key innovation area identified from patents. Spruce Biosciences's grant share as of February 2024 was 19%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11858932B2) discloses a method for treating polycystic ovary syndrome with functional adrenal hyperandrogenism (PCOS-FAH) by administering a CRF1 antagonist or a pharmaceutically acceptable salt thereof. The CRF1 antagonist is a compound of Formula (I), and the method involves administering the antagonist in various doses ranging from 5 mg to 400 mg total daily dose to the subject.
Furthermore, the method outlined in the patent involves reducing levels of specific hormones such as adrenocorticotropic hormone (ACTH), dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), 1ß-hydroxyandrostenedione (11OHA4), and 11ß-hydroxytestosterone (11OHT) by at least 10% from baseline. The compound of Formula (I) can be administered at doses between 1 mg/day and 200 mg/day and can be formulated as microparticles, capsules, or tablets. The patent also specifies that the method can be applied to pediatric patients or adult patients, offering a potential treatment option for individuals suffering from PCOS-FAH.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
