Sibeprenlimab is under clinical development by Visterra and currently in Phase III for IgA Nephropathy (Berger’s Disease). According to GlobalData, Phase III drugs for IgA Nephropathy (Berger’s Disease) have a 50% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Sibeprenlimab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Sibeprenlimab overview
Sibeprenlimab is under development for the treatment of IgA nephropathy (Berger's disease). It is administered through intravenous and subcutaneous routes. The drug candidate is a humanized Ig G2 monoclonal antibody developed based on hierotope technology. It acts by targeting the cytokine, A Proliferation Inducing Ligand (APRIL).
It was also under development for the treatment of Henoch-Schonlein Purpura.
Visterra overview
Visterra, a subsidiary of Otsuka Holdings Co Ltd, is a clinical-stage biopharmaceutical company that develops antibody therapies for the treatment of infectious diseases. The company’s pipeline products include VIS410, a monoclonal antibody designed to treat influenza A, VIS513, a monoclonal antibody for the treatment of dengue and VIS649, an anti-APRIL monoclonal antibody (mAb) for the treatment of Imumuglobulin A Nephropathy (IgAN). Visterra utilizes its hierotope platform to design and engineer antibody-based therapies that target specific regions and epitopes of pathogens. Visterra is headquartered in Cambridge, Massachusetts, the US.
For a complete picture of Sibeprenlimab’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
