Sibeprenlimab is a monoclonal antibody commercialized by Otsuka, with a leading Phase III program in IgA Nephropathy (Berger’s Disease). According to Globaldata, it is involved in 6 clinical trials, of which 3 were completed, and 3 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Sibeprenlimabs valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Sibeprenlimab is expected to reach an annual total of $88 mn by 2039 in the US based off GlobalDatas Expiry Model. The drugs revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drugs phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Sibeprenlimab Overview
Sibeprenlimab is under development for the treatment of IgA nephropathy (Berger's disease). It is administered through intravenous and subcutaneous routes. The drug candidate is a humanized Ig G2 monoclonal antibody developed based on hierotope technology. It acts by targeting the cytokine, A Proliferation Inducing Ligand (APRIL).
It was also under development for the treatment of Henoch-Schonlein Purpura.
Otsuka Overview
Otsuka is a holding company, which operates various businesses such as pharmaceuticals, nutraceuticals, consumer products, and other businesses through its subsidiaries. It focuses on the research and development, manufacture, and sale of medicines for the treatment of cancer, cardiovascular diseases, central nervous system disorders, ophthalmic diseases, gastrointestinal and respiratory diseases, infectious diseases, dermatological conditions, and allergies. The companys product portfolio includes pharmaceutical products, cosmedics, functional foods and beverages, fine chemicals, electronic equipment, functional chemicals, medical devices, and OTC products. It markets its products across North America, Europe, and Asia. Otsuka is headquartered in Minato-ku, Tokyo, Japan.
The company reported revenues of (Yen) JPY2,018,568 million for the fiscal year ended December 2023 (FY2023), an increase of 16.1% over FY2022. In FY2023, the companys operating margin was 6.9%, compared to an operating margin of 8.8% in FY2022. In FY2023, the company recorded a net margin of 6%, compared to a net margin of 7.7% in FY2022.
The company reported revenues of JPY519,517 million for the first quarter ended March 2024, a decrease of 3.7% over the previous quarter.
For a complete picture of Sibeprenlimabs valuation, buy the drugs risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
