Senju Pharmaceutical has patented a method for differentiating pluripotent stem cells into clinically applicable retinal ganglion cells. The process involves inducing differentiation through floating culture and promoting axon elongation via adhesion culture, which can also be used for screening substances for protective effects on retinal nerves. GlobalData’s report on Senju Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Senju Pharmaceutical, Nanoparticle drug conjugates was a key innovation area identified from patents. Senju Pharmaceutical's grant share as of July 2024 was 49%. Grant share is based on the ratio of number of grants to total number of patents.
Method for differentiating stem cells into retinal ganglion cells
The granted patent US12024714B2 outlines a novel method for screening substances that may have protective or regenerative effects on retinal nerves. The method begins with the differentiation of pluripotent stem cells into retinal progenitor cells through a floating culture technique. Following this, the retinal progenitor cells are further differentiated into retinal ganglion cells, again utilizing floating culture conditions. Once the retinal ganglion cells are established, they undergo an adhesion culture process that allows for the elongation of their axons, which is a critical step in assessing nerve regeneration.
In the final stages of the method, the test substance is introduced to the retinal ganglion cells with elongated axons. The effectiveness of the test substance is then evaluated based on its protective and/or regenerative effects on these cells. This systematic approach provides a framework for identifying potential therapeutic agents that could aid in the treatment of retinal nerve damage, thereby contributing to advancements in regenerative medicine and ophthalmology.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
