Sanofi‘s patent provides methods for screening, diagnosing, and treating acid sphingomyelinase disorders like Niemann-Pick disease. The claim outlines a method for treating acid sphingomyelinase deficiency in humans using recombinant human acid sphingomyelinase. The treatment involves administering increasing doses intravenously and measuring lyso-sphingomyelin levels in biological samples. GlobalData’s report on Sanofi gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Sanofi, NSAID cancer drugs was a key innovation area identified from patents. Sanofi's grant share as of May 2024 was 60%. Grant share is based on the ratio of number of grants to total number of patents.
Treatment of acid sphingomyelinase deficiency using enzyme replacement therapy
A recently granted patent (Publication Number: US11998592B2) discloses a method for treating acid sphingomyelinase deficiency in human subjects. The method involves administering recombinant human acid sphingomyelinase (rhASM) intravenously at increasing doses from 0.03 or 0.1 mg/kg to 3 mg/kg, followed by maintenance doses of 3 mg/kg or less. The levels of lyso-sphingomyelin (lyso-SPM) in biological samples collected within specific time frames after each dose are measured, with each dose administered two weeks apart.
Furthermore, the method includes administering maintenance doses at 1, 2, or 3 mg/kg, particularly in subjects with elevated lyso-SPM levels compared to healthy controls. The biological samples for measuring lyso-SPM levels can be collected as dried blood spots and are obtained before each subsequent dose is administered. This patent provides a structured approach to treating acid sphingomyelinase deficiency, offering a clear dosing regimen and monitoring strategy to assess the effectiveness of the treatment over time.
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