Rhenium (186Re) Obisbemeda is a small molecule commercialized by Plus Therapeutics, with a leading Phase II program in Recurrent Glioblastoma Multiforme (GBM). According to Globaldata, it is involved in 7 clinical trials, of which 3 are ongoing, and 4 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Rhenium (186Re) Obisbemeda’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Rhenium (186Re) Obisbemeda is expected to reach an annual total of $124 mn by 2037 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Rhenium (186Re) Obisbemeda Overview
Plus Therapeutics Overview
Plus Therapeutics is a developmental-stage pharmaceutical company, which focuses on the discovery, development, and manufacturing of complex and innovative treatments for patients with cancer and other life-threatening diseases. The company’s lead radiotherapeutic candidate, rhenium obisbemeda, is targeted at CNS cancers such as recurrent glioblastoma (GBM), leptomeningeal metastases (LM), and pediatric brain cancers (PBC). It is also developing Rhenium-188 NanoLiposome Biodegradable Alginate Microsphere (188RNL-BAM), for treating various solid organ cancers, including primary and secondary liver cancers, via intra-arterial injection. The company uses a proprietary nanotechnology platform to reformulate and improve conventional chemotherapeutics. Plus Therapeutics is headquartered in Austin, Texas, the US.
The company reported revenues of (US Dollars) US$4.9 million for the fiscal year ended December 2023 (FY2023), compared to a revenue of US$0.2 million in FY2022. The operating loss of the company was US$13.3 million in FY2023, compared to an operating loss of US$19.7 million in FY2022. The net loss of the company was US$13.3 million in FY2023, compared to a net loss of US$20.3 million in FY2022.
The company reported revenues of US$1.7 million for the first quarter ended March 2024, an increase of 27.7% over the previous quarter.
For a complete picture of Rhenium (186Re) Obisbemeda’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
