Rexlemestrocel-L is under clinical development by Mesoblast and currently in Phase III for Congestive Heart Failure (Heart Failure). According to GlobalData, Phase III drugs for Congestive Heart Failure (Heart Failure) have a 53% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Rexlemestrocel-L’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Rexlemestrocel-L overview
Rexlemestrocel-L is under development for the treatment of acute myocardial infarction, end-stage hypoplastic left heart syndrome, advanced (class II-IV) chronic congestive heart failure due to left ventricular dysfunction and end-stage ischemic heart failure. It is administered as intra-myocardial (intra-cardiac) injection. The therapeutic candidate is based on mesenchymal precursor cell (MPC) technology platform.
Mesoblast overview
Mesoblast is a regenerative medicine company that develops regenerative cell-based products. Its most advanced candidate, remestemcel-L, is in Phase III clinical trials under the brand name RYONCIL for the treatment of pediatric steroid-refractory acute graft versus host disease (SR-aGVHD). Mesoblast is advancing rexlemestrocel for localized inflammatory diseases including advanced heart failure, and end-stage ischemic heart failure, and MPc-06-ID (rexlemestrocel) for the treatment of chronic low back pain. The company employs its proprietary technology platform to discover and treat cardiac diseases, and hematological diseases, mesenchymal lineage adult stem cells (MLCs), spine and musculoskeletal disorders and immune-mediated and inflammatory conditions. The company has operations in the US, Australia, and Singapore. Mesoblast is headquartered in Melbourne, Victoria, Australia.
For a complete picture of Rexlemestrocel-L’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
