Raludotatug Deruxtecan is a monoclonal antibody conjugated commercialized by Daiichi Sankyo, with a leading Phase I program in Renal Cell Carcinoma. According to Globaldata, it is involved in 2 clinical trials, which are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Raludotatug Deruxtecan’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Raludotatug Deruxtecan is expected to reach an annual total of $15 mn by 2039 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Raludotatug Deruxtecan Overview
Raludotatug deruxtecan (DS-6000) is under development for the treatment of ovarian cancer, primary peritoneal cancer, fallopian tube cancer and renal cell carcinoma. It is a monoclonal antibody drug conjugate (ADC) comprises of a humanized anti-CDH6 IgG1 monoclonal antibody attached to a topoisomerase I inhibitor payload, an exatecan derivative, via a tetrapeptide-based cleavable linker It acts by targeting tumor cells expressing cadherin 6 (CDH6) and acts as topoisomerase I inhibitor. It is administered through intravenous route. It is being developed based on DXd ADC technology.
Daiichi Sankyo Overview
Daiichi Sankyo is a holding company, which carries out the research, development, manufacture, and marketing of pharmaceutical products. The company offers a wide range of prescription drugs, over the counter (OTC) drugs, vaccines, and others. Its portfolio encompasses medicines for cardiovascular, neurological, nephrological, diabetic, metabolic, and infectious diseases, and various types of cancers. Besides cancer, the company’s other research areas include rare diseases and immune disorders. Daiichi Sankyo sells its products through its group companies and an extensive network of medical representatives. It has operations in North America, South and Central America, Europe, and Asia. Daiichi Sankyo is headquartered in Tokyo, Japan.
The company reported revenues of (Yen) JPY1,601,688 million for the fiscal year ended March 2024 (FY2024), an increase of 25.3% over FY2023. In FY2024, the company’s operating margin was 13.2%, compared to an operating margin of 9.3% in FY2023. In FY2024, the company recorded a net margin of 12.5%, compared to a net margin of 8.5% in FY2023.
For a complete picture of Raludotatug Deruxtecan’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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