Puxitatug samrotecan is under clinical development by AstraZeneca and currently in Phase II for Endometrial Cancer. According to GlobalData, Phase II drugs for Endometrial Cancer have a 22% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Puxitatug samrotecan’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Puxitatug samrotecan overview
Puxitatug samrotecan (AZD-8205) is under development for the treatment of recurrent or metastatic solid tumors including breast cancer, cholangiocarcinoma, ovarian, biliary tract cancer, fallopian tube, peritoneal and endometrial cancers. The therapeutic candidate is an antibody-drug conjugate (ADC) specific to B7-H4 that uses a linker drug consisting of topoisomerase I linker-warhead. It is administered through intravenous route.
The drug candidate was also under development for the treatment of triple-negative breast cancer (TNBC).
AstraZeneca overview
AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.
For a complete picture of Puxitatug samrotecan’s drug-specific PTSR and LoA scores, buy the report here.
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