Praxis Precision Medicines. has been granted a patent for a method to treat essential tremor using an oral dosage form containing a specific crystalline anhydrous Form C hydrochloride. The invention also addresses conditions related to T-type calcium channel dysfunction, including various types of epilepsy and mood disorders. GlobalData’s report on Praxis Precision Medicines gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Praxis Precision Medicines, Peptide pharmacophores was a key innovation area identified from patents. Praxis Precision Medicines's grant share as of July 2024 was 17%. Grant share is based on the ratio of number of grants to total number of patents.
Treatment of essential tremor using specific oral dosage forms
The granted patent US12049448B2 outlines a method for treating essential tremor in patients through the administration of an oral dosage form containing a specific crystalline anhydrous Form C hydrochloride, referred to as Formula (II). The claims detail the characteristics of this compound, including its X-ray powder diffraction (XRPD) pattern, which must exhibit specific peaks at defined diffraction angles (2?), such as 26.6±0.2, 16.2±0.2, and 17.4±0.2. Additional claims specify the melting point onset of the compound at approximately 226.6°C, as determined by differential scanning calorimetry (DSC), and the potential inclusion of modified-release polymers, diluents, glidants, and lubricants in the formulation.
The patent further emphasizes the therapeutic efficacy of the method, indicating that it leads to a reduction in essential tremor severity as measured by various assessment scales, including The Essential Tremor Rating Assessment Scale (TETRAS) and its subscales. The claims also specify the composition of the dosage form, including the percentage of the crystalline compound, which ranges from about 0.9% to about 40% by weight. The method is particularly focused on alleviating upper limb tremors, providing a targeted approach to managing this condition in patients.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
